{"product_id":"medicinal-chemistry-9786206142058","title":"Medicinal chemistry","description":"SYNTHESIS AND CHARACTERIZATION OF 3,5- DIMETHYL PYRAZOLEAIM: To synthesize 3,5- dimethyl pyrazole in the laboratory and characterize the crude and re-crystallized product.APPARATUS\/INSTRUMENT REQUIRED: Reflux condenser, round bottomed flask, beaker, glass rod, pipette, buchner funnel, filtering flask, water bath, watch glass, capillary tube, thiele's tube, thermometer, electronic balance, vacuum pump and filter paper.CHEMICALS REQUIRED: Acetyl acetone, hydrazine hydrate, ethyl alcohol and n-hexane\/petroleum ether.CHEMICAL REACTION: REACTION MECHANISM: PRINCIPLE: Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine. For example, acetyl acetone and hydrazine gives 3,5-dimethyl pyrazole. The enamine and imine formed undergo cyclization to yield the product.PROCEDURE: 1. Take 0.06 moles of hydrazine hydrate in a 250 ml flask.2. To this, add 25 mL of ethyl alcohol with constant stirring.3. Now place the flask in an ice-old water or ice-bath and wait for 10 minutes.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Sunitha N, Appa Rao B\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e LAP Lambert Academic Publishing\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/07\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 80\u003cbr\u003e\u003cb\u003eBinding Type:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.28lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.19d\u003cbr\u003e\u003cb\u003eISBN:\u003c\/b\u003e 9786206142058\u003cp\u003e\u003ci\u003eThis title is not returnable\u003c\/i\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"LAP Lambert Academic Publishing","offers":[{"title":"Paperback","offer_id":40828231745651,"sku":"9.78621E+12","price":73.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0555\/9255\/0515\/products\/img_d3cdea5d-4977-46d8-9bf9-a5cd103ee68f.jpg?v=1684329271","url":"https:\/\/bookstorenmore.com\/en-de\/products\/medicinal-chemistry-9786206142058","provider":"Bookstore N More","version":"1.0","type":"link"}