{"product_id":"intrinsic-mechanism-of-anticancer-drugs-in-neurodegenerative-disorders-9781916706217","title":"Intrinsic Mechanism of Anticancer Drugs in Neurodegenerative Disorders","description":"\u003cp\u003eNeurodegenerative (NDDs) disorders are one of the most alarming medical illnesses\u003c\/p\u003e\u003cp\u003eaffecting the brain and nervous system. The Lack of understanding of the disease-leading\u003c\/p\u003e\u003cp\u003emechanisms makes the treatment options unavailable. Currently, an estimated 35.6 million\u003c\/p\u003e\u003cp\u003epeople are surviving with Dementia, and the number is presumed to triple by the next 30\u003c\/p\u003e\u003cp\u003eyears [1]. According to the report of the World Health Organization (WHO), in the next 20\u003c\/p\u003e\u003cp\u003eyears, NDDs affecting motor functions will be the second most widespread reason for\u003c\/p\u003e\u003cp\u003ehuman death [2]. NDDs are categorized based on clinical features- dementia, parkinsonism, \u003c\/p\u003e\u003cp\u003eor motor neuron disease, or based on the anatomic areas covered- spinocerebellar\u003c\/p\u003e\u003cp\u003edegeneration, frontotemporal degeneration and extrapyramidal disorders. In general, \u003c\/p\u003e\u003cp\u003esynucleinopathies, and TDP-43 proteinopathies are the most\u003c\/p\u003e\u003cp\u003ewidespread NDDs. Abnormal protein aggregation is the major hallmark feature of all\u003c\/p\u003e\u003cp\u003eNDDs associated with some fundamental processes such as progressive neuronal loss, \u003c\/p\u003e\u003cp\u003eneuroinflammation, dysfunction of the Ubiquitin proteasome system (UPS), abnormal\u003c\/p\u003e\u003cp\u003eautophagic processes, oxidative insult, and neuronal apoptosis\u003c\/p\u003e\u003cp\u003e(HD), and Multiple sclerosis (MS) are the major NDDs affecting the global health.\u003c\/p\u003e\u003cp\u003eAging is the biggest risk factor for various diseases, from cancer to NDDs. These agerelated\u003c\/p\u003e\u003cp\u003ediseases can be categorized into two groups. Loss-of-function diseases like NDDs\u003c\/p\u003e\u003cp\u003eare represented by the loss of cells, tissues, or optimal physiological functions. While gainof-\u003c\/p\u003e\u003cp\u003efunction diseases like cancer exhibit gain of cells and, sometimes, new cellular functions\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Dia Advani\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Self Publish\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/25\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 232\u003cbr\u003e\u003cb\u003eBinding Type:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.70lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.49d\u003cbr\u003e\u003cb\u003eISBN:\u003c\/b\u003e 9781916706217\u003c\/p\u003e","brand":"Self Publish","offers":[{"title":"Paperback","offer_id":41294053015667,"sku":"9.78192E+12","price":37.36,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0555\/9255\/0515\/products\/img_9fd6050e-16bc-464a-a190-706a8e403f89.jpg?v=1706030221","url":"https:\/\/bookstorenmore.com\/products\/intrinsic-mechanism-of-anticancer-drugs-in-neurodegenerative-disorders-9781916706217","provider":"Bookstore N More","version":"1.0","type":"link"}