Bioorganic Chemistry: A Chemical Approach to Enzyme Action

1 Introduction to Bioorganic Chemistry.- 1.1 Basic Considerations.- 1.2 Proximity Effects in Organic Chemistry.- 1.3 Molecular Adaptation.- 2 Bioorganic Chemistry of the Amino Acids.- 2.1 General Properties.- 2.2 Dissociation Behavior.- 2.3 Alkylations.- 2.4 Acylations.- 2.5 Biological Synthesis of Proteins.- 2.6 Chemical Synthesis of Proteins.- 2.7 Asymmetric Synthesis of a-Amino Acids.- 3 Bioorganic Chemistry of the Phosphates.- 3.1 Biological Role of Phosphate Macromolecules.- 3.2 General Properties.- 3.3 Hydrolytic Pathways.- 3.4 Other Nucleotide Phosphates.- 3.5 Biological Synthesis of Polynucleotides.- 3.6 Chemical Synthesis of Polynucleotides.- 3.7 Chemical Evolution of Biopolymers.- 4 Enzyme Chemistry.- 4.1 Introduction to Catalysis.- 4.2 Introduction to Enzymes.- 4.3 Multifunctional Catalysis and Simple Models.- 4.4 ?-Chymotrypsin.- 4.5 Other Hydrolytic Enzymes.- 4.6 Stereoelectronic Control in Hydrolytic Reactions.- 4.7 Immobilized Enzymes and Enzyme Technology.- 5 Enzyme Models.- 5.1 Host - Guest Complexation Chemistry.- 5.2 Micelles.- 5.3 Polymers.- 5.4 Cyclodextrins.- 5.5 Enzyme Design Using Steroid Template.- 5.6 Remote Functionalization Reactions.- 5.7 Biomimetic Polyene Cyclizations.- 6 Metal Ions.- 6.1 Metal Ions in Proteins and Biological Molecules.- 6.2 Carboxypeptidase A and the Role of Zinc.- 6.3 Hydrolysis of Amino Acid Esters and Amides and Peptides.- 6.4 Iron and Oxygen Transport.- 6.5 Copper Ion.- 6.6 Cobalt and Vitamin B12 Action.- 7 Coenzyme Chemistry.- 7.1 Oxidoreduction.- 7.2 Pyridoxal Phosphate.- 7.3 Thiamine.- 7.4 Biotin.- References.

Author: H. Dugas, C. Penney
Publisher: Springer
Published: 01/28/2012
Pages: 524
Binding Type: Paperback
Weight: 1.82lbs
Size: 9.61h x 6.69w x 1.05d
ISBN: 9781468400977

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