Nicotine and Related Alkaloids: Absorption, Distribution, Metabolism and Excretion

Plant metabolism. Mammalian metabolism: overview. Nicotine to cotinine. Nicotine to cotinine: enzyme induction. N-oxidation, N-methylation and conjugation reactions. Nicotine metabolism: beyond cotinine. Extrahepatic nicotine metabolism. Minor tobacco alkaloids. Pharmacokinetics of nicotine and metabolites in animals. Pharmacokinetics of nicotine and metabolites in humans. Factors influencing individual variation in nicotine pharmacokinetics. Analysis of nicotine. Chromatographic analysis of nicotine and metabolites. Nicotine and metabolites: pharmacokinetics models. New methods for probing the in vivo disposition of nicotine in humans. Aspects of metabolism of S- nicotine.

Author: John Wahren
Publisher: Chapman & Hall
Published: 09/30/1993
Pages: 320
Binding Type: Hardcover
Weight: 1.38lbs
Size: 9.21h x 6.14w x 0.75d
ISBN: 9780412557408