A decade ago, oestrogen-containing hormone therapy was viewed as a promising strategy for the prevention and treatment of dementia and age-related cognitive decline. However, treatment trials in women with Alzheimer's disease showed that oestrogens did not reverse cognitive impairment, and clinical trials in healthy older women indicated that oestrogens did not prevent cognitive decline. The Women's Health Initiative Memory Study trial even suggested an increased risk of dementia with treatment late in life. What happened? How are we to understand these findings? What are the implications for middle-aged and older women? What about testosterone, and what about men? And where do we go from here? This book brings together world-renowned experts in basic and clinical research on sex steroids, aging, and cognition to integrate existing findings with emerging new data, and offer challenging hypotheses on these key issues.
Author: Eef Hogervorst Publisher: Cambridge University Press Published: 09/24/2009 Pages: 292 Binding Type: Hardcover Weight: 1.75lbs Size: 9.70h x 7.50w x 0.80d ISBN: 9780521899376
Review Citation(s): Reference and Research Bk News 02/01/2011 pg. 292
About the Author Hogervorst, Eef: - Eef Hogervorst is Professor of Biological Psychology, Department of Human Sciences, Loughborough University, Loughborough, UK; Visiting Senior Research Fellow, Department of Public Health and Primary Care, University of Cambridge, UK; Visiting Professor, Department of Epidemiology and Public Health, University of Respati, Jakarta, Indonesia.Henderson, Victor W.: - Victor W. Henderson is Professor of Health Research & Policy (Epidemiology) and of Neurology & Neurological Sciences, Stanford University, USA.Gibbs, Robert B.: - Robert B. Gibbs is Professor of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA. Et al...